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The KEAP1-Nrf2 complex breaks down when the cell is exposed to oxidative stress, and the released Nrf2 is then transported into the nucleus and binds to antioxidant response elements [25, 26]

Nature 411 : 583587

Detection of ROS Cells were seeded in 6-well plates and treated with the indicated agents, followed by 10 mM H2DCFDA when cells grew to 70% confluence

Another important factor is a persons age at time of intervention, as nutritional interventions should ideally start at or before the observed cognitive decline (146)

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