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doi: 10.3389/fphar.2021.601626 Received 01 September 2020 Accepted 04 January 2021 Published 03 February 2021 Volume 12 - 2021 Edited by Santiago Gmez-Ruiz, Rey Juan Carlos University, Spain Reviewed by Kui Luo, Sichuan University, China Xiaowei Zeng, Sun Yat-Sen University, China Updates Copyright 2021 Gagliardi, Giuliano, Venkateswararao, Fresta, Bulotta, Awasthi and Cosco