Decreased levels of hydroxyl radical (HO), peroxynitrite (ONOO - ), RO 2 , and singlet oxygen, and decreased expression of COX-2 and iNOS and NF-kB activation are all antioxidant effects of melatonin (318, 319), pointing to the possibility that melatonin is beneficial in UC by lowering inflammation and regulating OS
Andreeff M , Marini FC, Westin S, Coleman R, Thall P, Al Jahdami V, Qazilbash M, Rezvani K, Timmons M, Heese L, Wang RY, Champlin RE, Shpall E, Olson A
Guna Collagen Dosage and Administration 2.1
This protective effect is likely attributable to improvements in metabolic disturbances, inflammation, and oxidative stress (140)
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doi: 10.3389/fvets.2018.00014