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Treat promptly per standard of care, and monitor until signs and symptoms resolve

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A study from The Netherlands (Riphagen, 2020) found that after 8.5 years of follow-up of an older cohort (median baseline age=65), a doubling of baseline MMA levels was associated with an increased risk of mortality (HR 11.48, CI 3.3239.64)

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In muscle injury model studies, muscle injury (such as trauma, exerciseinduced injury, or diseaserelated damage) triggers a series of pathophysiological processes including myofiber rupture, inflammatory responses, and muscle stem cell activation

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In the latter study, the researchers hypothesized that vitamin B12 may activate an inflammatory process in bacteria that normally lives on the skin, but which can promote acne when inflamed, according to Live Science

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