Enzymatic factors, which include proteins such as SOD, catalase, and enzymes involved in the synthesis of GSH, are also negatively influenced by hyperglycemia [329,330,331,332]
Disease Primers
AMG 133 demonstrated significant dose-dependent weight loss in a phase 1 randomized, double-blind, placebo-controlled clinical trial involving participants with obesity, along with an acceptable safety and tolerability profile [124]
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Superoxide anions (O 2 ), although weak oxidants, ultimately generate highly reactive and harmful species such as hydroxyl radicals (OH) and singlet oxygen ( 1 O 2 ), both of which contribute significantly to oxidative stress (Gulcin et al