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Molecular dynamics-guided optimization of BGM0504 enhances dual-target agonism for combating diabetes and obesity

Hong CG, Florida E, Li H, Parel PM, Mehta NN, Sorokin AV

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In fact, short-term glutamine breakdown induces lysosomal translocation and mTORC1 activation through Rag GTPase, then inhibits autophagy and promotes cell growth

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