Conditions include alcoholic liver disease, viral hepatitis, cirrhosis, and primary or metastatic liver cancer Renal dysfunction : Impaired kidney function reduces B12 elimination, causing accumulation even with normal intake Haematological conditions : Myeloproliferative neoplasms, chronic myeloid leukaemia, polycythaemia vera, and hypereosinophilic syndrome increase transcobalamin production, elevating total serum B12 Laboratory interference : Macro-B12 (immunoglobulin-bound B12) and assay interference can cause spuriously elevated results without true excess In clinical practice, unexplained hypercobalaminaemia should prompt investigation for underlying disease, particularly in patients without obvious supplementation history
B12 solution should be injected with air after the needle is inserted into the vial
When will I feel the effects of the B12 injection
Thus, individuals with food-bound vitamin B 12 malabsorption do not have an increased requirement for vitamin B 12
The therapys success is checked by looking at clinical markers
In summary, use the injections for as long as they are providing a clear benefit and need
