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However, the absence of human clinical trials means the safety profile in humans is entirely unknown

We have no doubt that you'll see plenty of headlines (maybe watered down) in the next few years for glutamate and CBD/NAC specifically

Biochem Biophys Res Commun 263(1):123129

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To address whether GSH improves systematically in diabetic patients on an anti-diabetic regimen over two months, we correlated glutathione to HbA 1C of non-diabetic subjects and diabetic patients above age 40 at the beginning (0 week), at 4 weeks and at the end of study at 8 weeks (Figure 2)

While it offers significant benefits for detoxification and aging, excessive intake can lead to unnecessary health risks