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10.1124/jpet.109.161711 127 YapB

In melanoma, downregulation of IGF-1 reduces the dry character of melanoma initiating cells, including the expression of dry markers (SOX2, Oct-3/4, CD24 and CD133) and functional properties (melanosphere formation, aldehyde dehydrogenase activity and side population) and eventually inhibiting the proliferation and metastasis of tumor cells (26)

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The identification of predictive biomarkers could further optimize these combination strategies (114, 115)

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