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Oxidative stress has also been reported as a major factor in the formation of uterine fibroid 48, 49 , indicating that these findings concur with previous investigations 50, 51

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Hypoxia promotes the conversion of cells from aerobic respiration to anaerobic respiration

We hypothesize that uncontrolled opening of glial hemichannels and pannexons may be a relevant downstream target that disturbs proper glia-to-neuron communication, affecting synaptic transmission in neural circuits crucial for alcohol rewarding

This causes the Foxo3 protein to lose its ability to perform transcriptional functions and causes it to move from the nucleus to the cytoplasm, where it is then targeted for degradation (John et al