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PMID: 27633659

The answer is complex, but it is likely in large part due to the combination of its ubiquity in the body and the significant role it plays

The cellular complexity-related features of apoptosis: involvement of organelles Apoptosis is a caspase-dependent RCD which was first described in 1972 based on a characteristic cellular morphology such as cell shrinkage, nuclear condensation, formation of apoptotic bodies, etc [71, 72]

Moreover, these expected proteasomal substrates enable proteome-wide screening of candidate proteins using quantitative proteomics from cell lysates

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