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The excessive increase of reactive oxygen species (ROS) leads to an increase in levels of Ca +2 ions, which play a critical role in the initiation and propagation of seizure, as well as results in the entry of the neurotoxin and inflammatory cells, which are considered mediators of seizure (Hassanzadeh et al., 2017)

2.2 Genetic factors Research on the genetic mechanisms underlying PD indicates that its onset can be attributed to single-gene mutations or the interaction of multiple genes with environmental factors

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Through these regulatory interactions, it contributes to coordinated cellular signaling within normal physiological frameworks

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Sun, Y., Chen, Y