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Numerous studies have demonstrated that the MAPK signaling pathway significantly affects TQ antineoplastic properties

"Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study"

Phase 2 trial (NEJM 2023) used a structured ramp to 12 mg/week but at trial doses of 8 mg and 12 mg, dropout from gastrointestinal events was substantial

Additionally, even within the same type of cancer, there can be substantial heterogeneity in terms of glutamine reliance based on genotype or subtype of cancer [65,66]

The protective effect of dexmedetomidine in a rat ex vivo lung model of ischemia-reperfusion injury