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Batt, A

In-vitro studies have reported that GHK-Cu can decrease the expression and activity of certain MMPs (like MMP-1 and MMP-2) while increasing the expression of TIMPs (TIMP-1, TIMP-2)

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Both enzymes consume ATP but only the former enzyme is subject to feedback inhibition by glutathione, which competes with glutamic acid for the active site

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doi: 10.1016/j.nut.2023.111992, PMID: [DOI] [PubMed] [Google Scholar] 50.Garcia D, Shaw RJ