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It is not subject to feedback inhibition by glutathione (GSH) and its substrates gamma-glutamylcysteine (GGC) and glycine are rapidly ligated to form glutathione (GSH)

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de Cabo R, Carmona-Gutierrez D, Bernier FM, Hall MN, Madeo F

Surprisingly, metformin systematically improves the characteristics and hallmarks of ageing, lowering epigenetic age by up to 6.1 years (frontal lobe)