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Epidemiologic studies have shown that high fruit and vegetable intake is associated with a reduced risk of certain cancers, but high doses of carotenoid supplements may be counterproductive in specific populations (49)

The effects will be monitored, and intervals adjusted as required

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In multipotent NPCs, Ngn1, Ngn2, and NeuroD2 retain the closed (H3K27me3) promoter conformation, whereas promoters of Sox4 and Sox11 become open (no H3K27me3

FOXO4-DRI targets the specific FOXO4-p53 anti-apoptotic interaction in senescent cells

Grant committees evaluate proposals based on the strength of the experimental design and the reliability of the methods used