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More recently, mGPDHs protective function was validated in vivo: in a mouse model of sepsis-induced acute lung injury, mGPDH knockdown exacerbated lung injury, vascular leakage, inflammation and oxidative damage, accompanied by elevated ferroptotic markers 100

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PAL acts as the switch for the phenylpropanoid biosynthesis pathway and plays an important role in resisting biotic and abiotic stressors [46, 47]

Additionally, the flavonoids found in fruits and vegetables, such as quercetin and curcumin, have been shown to support detoxification by increasing the activity of detoxification enzymes, including those involved in conjugation