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Development of AAV-Mediated gene therapy approaches to treat skeletal diseases
Nature 288, 675679
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The substance has attracted considerable attention on account of its multifarious pharmacological activities, which encompass antioxidant, anti-inflammatory, anti-fibrotic, anti-apoptotic, and anti-tumor effects, as well as cardioprotective properties ( in vitro and in vivo studies have demonstrated promising protective effects ( Significant efforts have notably been invested in developing novel drug delivery systems (DDS) and device-assisted administration strategies to enhance the targeting, solubility and bioavailability of Tan IIA, thereby achieving more efficient cardioprotection ( 2 Drug delivery systems and device-assisted administration systems for Tanshinone IIA 2.1 Drug delivery systems A drug delivery system (DDS) can be defined as a device or method that efficiently transports a therapeutic agent to its target site, with the aim of optimizing the drug's absorption, distribution, metabolism, and excretion (ADME) profile
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