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One central remaining question would be how the amino acid G1228 can be implicated in GSH efflux stimulation while it is not located in or near GSH binding sites

Kolovrat et al., 2020) bypassing the occlusion (Vukojevic et al., 2018

doi:10.1007/s11095-013-1007-6

These medications target fundamentally different hormonal systemsone endocrine, one metabolic-signalingwhich suggests additive rather than overlapping effects