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Clinical Update 9/18/2020 Vitamin D for Failing Hearts

This process may be less efficient in individuals with certain metabolic or absorption issues

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8 weeks (2.55 mg/wk): ~3 vials 12 weeks (2.57.5 mg/wk): ~6 vials 16 weeks (2.510 mg/wk): ~10 vials Insulin Syringes (U-100, 1 mL) Per week: 1 syringe (once-weekly dosing) 12 weeks: 12 syringes 24 weeks: 24 syringes 48 weeks: 48 syringes Bacteriostatic Water (10 mL bottles) Use 2.0 mL per vial for reconstitution

In C2C12 myotubes, NNMT inhibitor treatment produces concentration-dependent increases in NADH levels (50% higher at 30 M) and reduces NAD+/NADH ratios by 25-40%

They're all downstream of the same underlying cellular environment