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Article 13

10.1124/dmd.108.024745 180 TaiL

To determine CNS penetrance, the levels of D and Q in CSF were measured using high-performance liquid chromatography with tandem mass spectrometry

It is highly improbable

The results suggest that epithelial cells are a susceptible target for PET MNPs and underscore that both the respiratory tract and the skin may serve as potential target organs for their toxic effects

Similarly, in male mice, a biogenic immune stressor producing sustained IFN- elevations induced chronic increases in both peripheral and brain IDO activity, accompanied by widespread TRP depletion, indicating that prolonged cytokine signalling drives central and peripheral TRP loss [68]