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This suggests that even if a change were to occur, it would require continuous, long-term administration, which increases health risks

J Clin Oncol 28(16):2755-60, 2010

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Additionally, NRC-03 and NRC-07, two AMPs from the pleurocidins AMP family, exhibited equal killing effect at a concentration of 50M on normal MCF7 cells and on paclitaxel-resistant breast cancer cell line MCF7-TX400 that possess 2.6 times of P-gp expression more than the normal MCF7 cells, achieving about 60% of cell killing rate

the substantial amount is at least 70 - 80 % in 10 - 12 hrs, preferably at least 90 % in 12 hrs and most preferably at least 95 % in 12 hrs