Other toxic compounds involved in Parkinson development: Paraquat and 6-OHDA The pesticide ,-dimethyl-4,4-bipyridinium dichloride (paraquat), which shares similar structure with MPP + , impairs mitochondrial functions by inducing an augmented production of oxidative stress and 4-hydroxynenal [87]
4(2): 10822.Bavarsad Shahripour R, Harrigan MR, Alexandrov AV
DOI: 10.1016/j.clnu.2017.10.024 [DOI] [PubMed] [Google Scholar] 55.Speeckaert M, Huang G, Delanghe JR, and Taes YE
Researchers first studied it for its protective effects on the stomach lining and digestive tract, where it showed promise for ulcers, inflammatory bowel disease, and other gut-related conditions
This was done in the presence of the CI-linked substrates pyruvate (5 mM), malate (2 mM) and in the absence of ADP (2.5 mM) followed by the addition of cytochrome c (10 M) to test for the integrity of the mitochondrial outer membrane (cytochrome c control efficiency)
Yap SY, et al
