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282 Similarly, lactylation of malate dehydrogenase 2 (MDH2), a key enzyme of the TCA cycle, induces ferroptosis of cardiomyocytes by inhibiting the TCA cycle and impairing mitochondrial function, thereby resulting in myocardial ischemiareperfusion injury (MIRI)
L-Glutathione is a powerful antioxidant that plays a crucial role in detoxification, immune function, and protection against oxidative stress
They are classified as research chemicals, meaning they can be sold legally for research purposes but are not approved as medicines
3.3.2.1 Urolithin A Urolithin A, a natural gut metabolite of ellagic acid and ellagitannins, rich in nuts, is a safe mitophagy activator ( via promoting Nrf2 translocating into nucleus (Zhang et al., 2022c), but also ameliorates hyperuricemic nephropathy via enhancing PINK1-associated mitophagy in renal TECs (Zhang et al., 2022a)
[DOI] [PMC free article] [PubMed] [Google Scholar] 7.Sikiric P., Hahm K.B., Blagaic A.B., Tvrdeic A., Pavlov K.H., Petrovic A., Kokot A., Gojkovic S., Krezic I., Drmic D., et al
It helps calm inflammation
