New or worsening tingling, numbness, difficulty with balance or coordination, muscle weakness, or cognitive changes should prompt same-day clinical assessment
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[2] Once administered intramuscularly, B12 is gradually released into the bloodstream and transported to the liver, where approximately half of the body's total B12 stores are held
These effects are described in the literature as epigenetic modulation, meaning changes in how genes are expressed rather than changes to the underlying DNA sequence
Published research data is limited regarding long-term human side effects
(PubMed) Lam-Tse WK, Batstra MR, Koeleman BP, et al