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Parameters to monitor ECG Rebound hypertension Cholesterol levels Pulse (apical and radial) Glucose levels Direct Vasodilators This medication class (second-line agents) is best avoided unless necessary to treat refractory hypertension that is unresponsive to all other agents

In animal models it has been associated with tendon, ligament, muscle and gut healing , angiogenesis and cytoprotection effects reported preclinically, not confirmed in controlled human trials