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B12 needs can change during pregnancy, and any supplementation should be guided by a blood test and proper medical advice, not a general wellness decision

Very high doses (such as those used for cyanide poisoning) should be used with caution and only if the potential benefit outweighs the risk

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Pharmacokinetic profiles for the compound place its plasma half-life in the neighborhood of 45 minutes after parenteral administration in animal models, which informs typical dosing intervals in published experiments