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Dose ranges come from allometric scaling (using a math formula to translate a mouse mg/kg dose into a human dose) and from research community use

If the bodys storage capacity is exceeded as a result of high-dose and, in particular, parenteral administration, the portion not retained is excreted in the urine

Although B12 is the only one of the water-soluble vitamins that can be stored in the body (mainly in the liver), it does not appear to accumulate negatively

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While animal studies consistently demonstrate beneficial effects across diverse injury models and tissue types, the absence of adequately powered, controlled human clinical trials prevents definitive conclusions about efficacy in human disease

Safe administration of intravenous vitamin C