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The pathophysiology of IBD is multifactorial and involves a complex interplay of genetic, environmental, epithelial, microbial, and immunologic factors (140, 141)

It is proved that the oxidation of amino acids leads to the formation of cross-links, fragmentation, unfolding, and conformation changes in the protein (Saremnezhad et al

Yao et al., 2006), and may be explained in part by mitochondrial dysfunction

Exercise itself generates free radicals as a normal part of muscle metabolism useful in moderation, but a bigger antioxidant demand on heavy training days

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