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Pollard & Pomfrett suggest that DSIP administration doesnt induce tolerance,4 but theirs isnt the consensus conclusion

The removal process typically requires multiple sessions over several months to a year, depending on the type and depth of the pigment

This creates a regional pattern that does not resemble the results obtained with any other serotonergic drug using this method. Why This Matters This nigrostriatal focus is mechanistically intriguing because these regions are heavily involved in motor control, reward processing, and motivation

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