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370 Second, similar to SSRIs, SNRIs also inhibit SERT, resulting in an increased concentration of 5-HT in the synaptic cleft

It is well known that PDE5I is the first-line treatment recommended by guidelines and is effective for various organic ED, including MetS-associated ED

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It may instead show disease-related problems, such as abnormal fermentation, poor absorption or use, or wrong spatial distribution

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2 Department of Surgery, North Middlesex Hospital, London, UK Correspondence: Peeyush Sharma, North Middlesex Hospital, British Institute of Aesthetic Plastic Surgery, Maxwell Road, Peterborough, Cambridgeshire, PE2 7JE, United Kingdom, Tel +44 01733 396171, Email [email protected] Abstract: Treatment of dark skin with glutathione has become popular due to its depigmenting properties and low toxicity