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Exposure to heat and light can degrade active components, reducing the products efficacy

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Meanwhile, we observed that the viral proteins of CAV20-wt and CAV20-BSOr virus (Figure 6B, lanes 14) share a similar binding pattern to GSH (Figure 6B, lanes 58) as their PV1 counterparts, indicating that the interaction of GSH to capsid proteins is a general phenomena within C-cluster enteroviruses

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Its usually a co-infection, a concurrent infection with other tick-borne diseases