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Kaczmarek A, Vandenabeele P, Krysko DV

Deficiencies in B12 or defects in methionine synthase will result in 5-methyl-THF trapping with the result being the development of megaloblastic anemia due to the block in nucleotide production and the inability of bone marrow erythroblasts to proceed through S-phase of the cell cycle

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It is not clear how DHA affects brain function, but changes in DHA content of neuronal cell membranes could alter the function of ion channels or membrane-associated receptors, as well as the availability of neurotransmitters (94)

Brain and Central Nervous System: Vitamin B12 is stored in small amounts in the brain and central nervous system, reflecting its importance in maintaining neurological health

On the other hand, the results of systematic reviews by Cochrane (100)