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Pharmacokinetics: Cyanocobalamin is administered intranasally, orally, and parenterally, while hydroxocobalamin is administered only parenterally. Once absorbed, vitamin B12 is highly bound to transcobalamin II, a specific B-globulin carrier protein and is distributed and stored primarily in the liver as coenzyme B12. The bone marrow also stores a significant amount of the absorbed vitamin B12. This vitamin crosses the placenta and is distributed into breast milk. Enterohepatic recirculation conserves systemic stores. The half-life is about 6 days (400 days in the liver). Elimination is primarily through the bile; however, excess cyanocobalamin is excreted unchanged in the urine

Diagnosis of deficiency Diagnosis of vitamin B12 deficiency is mainly based on laboratory blood tests

Designed for use as a reconstitution water in laboratory settings

For those looking at peptide alternatives, tesofensine and 5-amino-1MQ offer different mechanisms of action

It simply passes through and is excreted

Microdosing Semaglutide Split-dosing protocols for improved tolerability