KPV to syntetyczny tripeptyd skadajcy si z trzech aminokwasw: lizyny (K), proliny (P) i waliny (V)
A cluster of at least three of five of the following medical conditions: abdominal (central) obesity, elevated blood pressure, elevated fasting plasma glucose, high serum triglycerides, and low high-density lipoprotein (HDL) levels
GPx activity is associated with an increased risk of major adverse cardiovascular events at 1 year following an acute coronary syndrome
Similarly, TGR5 activation elevates intracellular cAMP levels, leading to downstream activation of protein kinase A (PKA) and exchange protein directly activated by cAMP (Epac), which suppresses NF-B signaling, inhibits NLRP3 inflammasome activation, and can promote macrophage polarization from the pro-inflammatory M1 phenotype toward the anti-inflammatory M2 phenotype 148
Statements Author contributions TW: Writing review & editing, Visualization, Writing original draft
Grigorev VV, Ivanova TA, Kustova EA, Petrova LN, Serkova TP, Bachurin SO