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These include myocardial I/R injury, diabetic cardiomyopathy (DCM), sepsis-induced cardiac injury, hypertrophic cardiomyopathy, atherosclerotic cardiovascular disease, HF, aortic aneurysm (AA), and hypertension (Figure 7)

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However, although host immune response has crucial role in COVID-19 pathology, opinions on the use of anti-inflammatory therapies, especially in critically ill patients, are conflicting ( DPP-4 inhibitors are able to suppress inflammatory signalling and proliferation of vascular smooth muscle cells ( Figure 1 depicts the proposed mechanism of beneficial effects of DPP-4 inhibition on SARS-CoV-2 damaged lungs and other organs

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