When to Consider Supplementation Supplements tend to play a supportive role once foundational lifestyle factors are in place: After optimizing diet and sleep When lab work shows insufficiencies During specific life stages or increased stress, with healthcare guidance Used this way, supplements can help fill gaps rather than function as stand-alone fixes
Intrinsic (mitochondrial) pathways are also activated, with pro-apoptotic Bcl-2 family members (Bid, Bak, Bax) promoting mitochondrial outer membrane permeabilization, cytochrome C release, and apoptosome formation (cytochrome C + APAF-1 + procaspase-9)
Lignans , another type of phytoestrogens, are found in virtually all plant foods but are particularly concentrated in flax and sesame seeds
Bei subkutaner Anwendung: 12 mg, 23 pro Woche
For example, a 2020 study found: Genetic predisposition to elevated serum IGF-1 levels was associated with higher risk of type 2 diabetes and coronary artery disease. The researchers note: Abnormal serum IGF-1 levels are associated with an increased risk of type 2 diabetes and cardiovascular diseasethe role of IGF-1 levels within the normal range in cardiometabolic disease remains unclear. 4
doi: 10.1515/bmc-2019-0022 167
