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Our findings describe a role for mitochondrial plasticity as a mechanism for acute 5FU tolerance in CRC cells: mitochondrial changes acutely adopted by CRC cells in response to 5FU-based standard-of-care treatment result in increased mitochondrial biogenesis, which provides metabolic support for increased pyrimidine scavenging by UCK2 to resolve nucleotide stress
Site-directed mutagenesis of the first disulfide bond (Cys186Cys406 in A
doi: 10.1016/j.cell.2018.02.048 66 DuJWangTLiYZhouYWangXYuXet al
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A Report of the American College of Cardiology Foundation Task Force on Clinical Expert Consensus Documents (Writing Committee to Develop an Expert Consensus Document on Complementary and Integrative Medicine)
10.1212/01.WNL.0000055901.58642.48 7
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