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As evident from the increase in plasma Urea levels, renal function indeed declines in wildtype mice as they age (Fig.6A

In all cases, satisfactory linear regression coefficients were obtained (between 0.9752 and 0.9921), confirming that this mathematical model works reasonably well

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Fang Y, Chen X, Tan Q et al (2021) Inhibiting ferroptosis through disrupting the NCOA4-FTH1 interaction: a new mechanism of action