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A subgroup of individuals with autism may show a functional undermethylation pattern involving low methylation reserve, high histamine, altered SAM or SAH, folate sensitivity and increased nutrient demand

HO-1 is positively regulated by Nrf2 (Yan et al., 2023)

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(19) Cystic fibrosis leads to suppressed glutathione levels and the impaired ability to produce more at a normal rate

however, current treatment methods, including surgery, chemotherapy, radiotherapy, targeted therapies, and immunotherapy, demonstrate limited success in effectively treating cancer [176]

Lahiri, S