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These agents indirectly inhibit fluid volume increases by inhibiting angiotensin IIstimulated release of aldosterone

Ann Allergy Asthma Immunol 105(1):7584

In order to mitigate this effect on resistance in non-target organisms, ideally the highest safe dosage should be chosen

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5 Reactive oxygen species as oxidizing agents: impact on cysteine proteinases and cellular homeostasis It has long been established that disturbances in reactive oxygen species (ROS) regulation generate highly reactive cellular environments, profoundly influencing intracellular signaling pathways and contributing to oxidative stress