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It can also act as an adjunct therapy to reduce oxidative stress in medical treatments

PMID: 26220150

In total, we generated six LMNA transgenic zebrafish lines: LMNA (WT), 3 novel and 2 known pathogenic mutant lines, including LMNA (L35P), LMNA (E358K), LMNA (R453W), LMNA (W520G), and LMNA (A539V), and which were validated by fin-clip, and the presence of the intended mutations was confirmed by comparing them to the LMNA (WT) sequence (Fig

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However, the addition of these chemotherapeutics does not yield improved clinical outcomes, presumably because simtuzumab exclusively inhibits extracellular LOXL2

Therefore, simply reducing iron exposure is not an effective method for managing CKD, and maintaining iron balance should be approached cautiously