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The dose of BAY11-7082 was chosen based on our preliminary results of dose response, which showed that 10 M BAY11-7082 significantly increased the number of surviving SGNs after cisplatin damage in vitro (Supplementary Figure 2)

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In theory-based modeling strategies, the whole blood concentration ( C wb ) of tacrolimus is converted into plasma concentration ( C p ) because of saturated binding to red blood cells