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Although generally safe, injections should be used with caution in people with a history of allergic reactions to cobalamin or in people with Leber's disease (hereditary optic neuropathy), as B12 may worsen the condition

7,8 Therefore, the dynamic NAD + and its metabolites levels, in response to diverse cellular stress and physiological stimuli, rewire biological processes via post-synthesis modification of fundamental biomolecules, including DNA, RNA and proteins

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High-dose vitamin B12 therapy has been shown to be effective in reducing neuropathic pain in patients with diabetic neuropathy, highlighting its potential as a valuable treatment option . More research has looked at how different ways of taking B12 work

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