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Future work will address the efficacy of Dihexa as a hair cell protect in mammalian models and against additional aminoglycosides

Dalton, T.P., et al., Genetically altered mice to evaluate glutathione homeostasis in health and disease

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Cagrilintide has a half-life of about 78 days (roughly 159195 hours measured in a Phase 1b study), and tirzepatide about 5 days (approximately 120 hours)

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This is exemplified in animal models which temporarily reduce astrocyte expression and have decreased expression of tight junction proteins, which is restored to normal levels when astrocytes are repopulated into the targeted region [44]