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To characterize compound engagement of TGR in adult worms ex vivo, the GSH/GSSG ratio was measured for compounds in Table 1

& Ding, J

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Under typical circumstances, the body sustains a balance between oxidation and antioxidation, preventing ROS overaccumulation and subsequent disruption of bone metabolism

Further mutants are obviously necessary to decipher the exact role of Tyr110 and to precisely map the glutathione interaction sites in future studies