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Homocysteine and risk of premature coronary heart disease

Hydroxyl radicals are extremely reactive and may cause extensive damage to cellular components

B, Adenocarcinoma

These alterations result in a significantly extended half-lifeup to 120 times longer than native IGF-1due to reduced binding affinity to insulin-like growth factor-binding proteins (IGFBPs)

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To assess whether this interaction is physiologically relevant, we immunoprecipitated ASXL1 from soluble nuclear extracts of K562 cells expressing Flag-Strep-tagged ASXL1 and identified potential ASXL1-binding partners by mass spectrometry (MS)