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Secondary efficacy outcomes included periodontal probing depth (PD), gingival recession (GR), tooth mobility (TM), bleeding on probing (BOP), and bone defect depth (BDD) at 6 months post-treatment

L2-Cmu does not perturb glucose homeostasis in older mice We then evaluated effects of chronic IGF-1R mAb treatment on energy and glucose homeostasis in an initial cohort of older mice

As we age, the efficiency of various cellular processes declines

a maximum dose of 4 g/day)