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12 Kaltenberg J, et al

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The ferroptosis pathway involves several critical mechanisms: iron uptake via transferrin receptor, ferritinophagy mediated by nuclear receptor coactivator 4 (NCOA4), iron export through ferroportin regulated by hepcidin, accumulation of lipid peroxides via the Fenton reaction, and antioxidant defense via glutathione peroxidase 4 (GPx4) and glutathione (GSH)

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[17] These receptors are predominantly found in the suprachiasmatic nucleus of the hypothalamus, which serves as the bodys master circadian clock, as well as in various other brain regions including the hippocampus, cortex, and brainstem