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For chronic plasticity enhancement or age-related cognitive decline studies, Dihexa's sustained upregulation of synaptic markers (PSD-95, synaptophysin) and dendritic spine density provides superior durability compared to Cerebrolysin's transient effects that plateau after 46 weeks

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The functional impact of these abundance and localization changes were determined with pulse chase experiments using labeled metabolic substrates, bioenergetics, and metabolite quantification